Scientist (Aquatic Model)

  • Location: Frederick, Maryland
  • Type: Contract
  • Job #38718

NCI Frederick, MD


Supports the planning and execution of research experiments in the context of the laboratory's overall research program.

· Independently direct and conduct special research projects that have a high priority for the laboratory with special emphasis in the development of novel research treatments

· Work with animal models e.g., zebrafish and mouse and/or tissue cultures e.g., cell lines and induced pluripotent stem cells, iPSC; use molecular biology and genetics techniques e.g., RT-PCR, in situ hybridization, Western blotting, and immunohistochemistry, morpholino and CRISPR-Cas9-sgRNA gene knockdown

· Apply standard animal techniques such as genotyping and husbandry

· Manage colony of mice for genetics experiments, including setting up mating pairs, genotyping mice and harvesting tissue embryos

· Develop, design and recommend further experimental work and approaches to the research

· Perform forward and reverse genetic and pharmacological screenings

· Design and conduct experiments and studies requiring the application of a broad professional knowledge of scientific theories and principles

Evaluates, analyzes and interprets research data, communicates results and methods in reports, presentations, and manuscripts.

· Write technical reports and prepare manuscripts.

· Identify outcomes relevant to the research

· Acquire, organize, and analyze experimental data and perform statistical analysis

· Maintain a detailed and up-to-date electronic laboratory notebook detailing all experiments

Coordinates with junior staff to modify research protocols.

· Coordinate projects being developed in the laboratory, proposing research strategies and monitoring their progress.

· Meet regularly to train and oversee experiments of junior trainees (e.g., summer interns and IRTA students)

· Work with staff to confirm assay results and evaluate new techniques and instruments; search literature; propose, design and test alternative assays for difficult screening targets; confirm assay results; develop secondary assays

· Suggest alternative or complementary approaches to experiments

Presents research at national scientific meetings and symposia.

· Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals; prepare PowerPoint presentations as appropriate.

· Review, edit, and, as needed, write first drafts of papers, posters and manuscripts.

· Prepare oral presentations and posters for internal and external groups conferences

· Co-author manuscripts on research projects; publish in peer-reviewed journals


  • Molecular biology, including molecular cloning, DNA/RNA purification, polymerase chain reaction (PCR, including qPCR, RT-PCR, RT-qPCR)
  • Animal handling, genotyping: Zebrafish
  • Animal handling, genotyping: Mouse
  • Cell culture techniques
  • Gene expression analysis, including in situ hybridization, immunofluorescence/immunohistochemistry, Western blotting
  • Data analysis, presentation
  • Tissue dissection and sectioning
  • Manuscript writing
  • CRISPR design/injection (zebrafish)
  • Microscopy (light/fluorescent)
  • Ordering supplies


  • MS Office applications (Outlook, PowerPoint, Word, Excel)
  • Reference management software (e.g., Endnote)
  • Software for figure creation such as Adobe Illustrator or Adobe Photoshop
  • Adobe Acrobat


· MS degree in developmental biology, genetics or molecular biology is required; Ph.D. degree is desirable

· Prior experience animal models including zebrafish and mouse


The world famous “Building 10” ON NIH’s main campus in Bethesda Maryland


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Equal Employment Opportunity (EEO) Information

While the position you're applying for may not be for a government role, Astrix is a governmental contractor and, as such, is required to collect certain information in its applicants. Astrix is an Equal Opportunity Employer and does not discriminate against any applicant for employment, or any employee because of age, color, sex, disability, national origin, race, religion, or veteran status. Completion of these fields will not affect your opportunity for employment or the terms or conditions of your employment.

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