Medicinal Chemist

  • Location: Marlborough
  • Type: Direct Hire
  • Job #37286

Job Title: Medicinal Chemist 
Location: Marlborough, MA 

Essential Functions:

  • Apply medicinal chemistry principles and synthesis capabilities in drug discovery projects focused on CNS disorders.

  • Manage chemistry FTEs and other CRO projects effectively to ensure optimal productivity.

  • Lead or co-lead projects to develop hits to leads and ultimately into clinical candidates.

  • Facilitate expansion of the Discovery research portfolio into new CNS disease opportunities.

  • Develop strategies for expansion of the corporate privileged compound library and identify new opportunities with respect to research and technology.

  • Work as a drug discovery partner with Discovery Pharmacology to initiate and prosecute new research projects, with Legal to develop effective patent strategies, and with Translational Medicine & CMC to ensure efficient technology transfer for emerging drug candidates.

  • Represent the science of the company internally and externally.

  • Collaborate with DRD for synergy and maximal productivity.


Minimum Education, Experience, Knowledge and Skills Required:

  • PhD in Organic Chemistry with > 6-8 years small molecule drug discovery experience; CNS research experience is a plus.

  • Skilled and comfortable with a fully outsourced research model.

  • Dynamic and creative individual with strong problem-solving and small molecule drug design abilities.

  • Excellent project leadership skills, work well in a team, be objective-driven, and understand the importance of project timelines.

  • Understanding of the biology of potential drug targets and systems biology.

  • Practical knowledge of the use of in vitro ADMET and in vivo PK to support lead generation and optimization.

  • Thorough understanding of process/strategy of intellectual property formation, in partnership with Legal, in the crafting of IP strategies and the use of IP to enhance the value of company programs.

  • State-of-the-art knowledge of technologies, processes and best practices and consistent contribution to organic chemistry/medicinal chemistry scientific and patent literature.

  • Keen awareness of the business of drug development and the ability to balance business and scientific goals in achieving success.

  • Outstanding oral and written communication skills.

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Equal Employment Opportunity (EEO) Information

While the position you're applying for may not be for a government role, Astrix is a governmental contractor and, as such, is required to collect certain information in its applicants. Astrix is an Equal Opportunity Employer and does not discriminate against any applicant for employment, or any employee because of age, color, sex, disability, national origin, race, religion, or veteran status. Completion of these fields will not affect your opportunity for employment or the terms or conditions of your employment.

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